PRF is safe, with no major side effects that you need to worry about. The treatment uses the platelet rich fibrin from the patient’s blood without adding any additives or anticoagulants to form a clot under the skin. However, unlike synthetic fillers, the procedure uses the patient’s platelets and natural fibrin, minimizing adverse reactions. The only side effects that can occur are mild pain, swelling, soreness, and minor bruising. Instead of waiting for the pain to go away on its own, it can be rapidly ameliorated with topical anesthetic and ice. If you are considering a PRF facial treatment, we recommend discussing this with your GLO Skin Care provider. Even if there aren’t many contraindications associated with the procedure, patients with low platelets or taking anti-clotting medications should avoid PRF.